Samuel Oevgü Yasmin on Muck Rack

Samuel Oevgü Yasmin

As seen in: Nature
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Articles

Inhibition of LDHB triggers DNA damage and increases cisplatin sensitivity in pleural mesothelioma - Oncogenesis

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By Ren-Wang Peng, Samuel Oevgü Yasmin
| Nature
Abstract Pleural mesothelioma (PM) is an aggressive, asbestos-linked cancer with limited treatment options and a poor prognosis. Lactate dehydrogenase B (LDHB) converts lactate to pyruvate, and its silencing reduces mitochondrial metabolism, particularly nucleotide synthesis. However, whether and a role of LDHB in PM is unclear. This study aimed to investigate the effects of silencing LDHB in PM cells and their response to chemotherapy.
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