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Sander Barnhoorn

As seen in: Nature, BioRxiv
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Articles

Elevated baseline DNA damage and hypomethylated circulating free DNA distinguish frailty from healthy aging

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By Stefania Farina, Sander Barnhoorn, Martina Sette, Cesar Payan-Gomez, Daisy Sproviero, Jean A. Helmijr, Maurice Jansen, John Martens, Monica Pinoli, Franca Marino, Alfredo Costa, Matteo Cotta Ramusino, Silvia Cerri, Fabio Blandini, Chiara Milanese, Pier G. Mastroberardino
| Nature Verified
Abstract Aging is a primary risk factor for several diseases, including neurodegenerative disorders and cancer, with DNA damage accumulation being one of the key drivers. Frailty is a severe form of aging that affects many older adults and is characterized by dysfunction across multiple body systems, leading to increased vulnerability and late-life disability. The pathogenic mechanisms differentiating frailty from healthy aging, however, remain unclear.
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Orthogonal analysis of mitochondrial function in Parkinson's disease patients

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By Chiara Milanese, Tracy Li, Sander Barnhoorn, Lieke Dons
| BioRxiv
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