Sandesh Ramchandra Jadhav on Muck Rack

Sandesh Ramchandra Jadhav

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Articles

Quality-by-design optimized reversed phase-high performance liquid chromatography method for quantification of everolimus in bulk drug and nanoparticle-based formulations

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By Ashutosh Gupta, Deepanjan Datta, Namdev Dhas, Sandesh Ramchandra Jadhav, Viola Colaco, Ritu Kudarha
| Nature Verified
Abstract Everolimus, a potent mTORC1 inhibitor used in various oncological and immunological indications, requires precise quantitative analysis due to its narrow therapeutic window and susceptibility to pharmacokinetic variability. This study aimed to develop and validate a robust, sensitive, and cost-effective reverse-phase high-performance liquid chromatography method for EVR quantification in bulk drugs, marketed formulations, and nanoparticle-based delivery systems.
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