Sandra Schamus-Hayes on Muck Rack

Sandra Schamus-Hayes

As seen in: Nature
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Articles

Centromeric footprints preserve telomere integrity in ALT cancers

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By Ragini Bhargava, Megan A Mahlke, Tobias Schmidt, Christoph Bartenhagen, Baylee Smith, Katherine Ramsey, Michelle L. Lynskey, Anne R. Wondisford, Michael Calderon, Simon Watkins , Jennifer Bone, Alok Joglekar, Matthias Fischer , Jan Karlseder, Yael Nechemia-Arbely, Roderick J. O’Sullivan, Takoda T. Zuehlke, Ray W. Bowman II, Jean-Baptiste Ouriou, Sandra Schamus-Hayes, April E. Williams-Wehner
| Nature
Abstract Alternative lengthening of telomeres (ALT) is a specialized telomere extension mechanism associated with 5–10% of all cancers1. Although ALT has been linked to epigenetic dysregulation and genome instability, specific genomic and epigenetic rearrangements generated after ALT activation have not been identified.
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