Reducing waste Cancer is often associated with the development of cachexia, a severe muscle wasting process for which there are no specific therapies. The precise mechanisms and the molecular players involved in cancer-associated muscle wasting remain to be identified. Here, Sartori et al. showed that bone morphogenetic protein (BMP) was reduced in patients and rodent models. This reduction caused neuromuscular junction impairments and subsequent denervation that caused muscle mass reduction.
