Sanduni Deenalattha on Muck Rack

Sanduni Deenalattha

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Articles

Characterizing 3D RNA structural features from DMS reactivity

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By Sanduni Deenalattha, Chris P Jurich, Bret Lange, Darren Armstrong
| biorxiv.org
Abstract Dimethyl sulfate (DMS) chemical mapping probes RNA structure, where low reactivity is generally interpreted as Watson-Crick (WC) base pairs and high reactivity as unpaired nucleotides. Studies examining DMS reactivity of RNAs with known 3D structures have identified nucleotides that deviate from this interpretation with distinct solvent accessibility and hydrogen bonding patterns. Understanding the frequency of these outliers and their recurring structural 3D features remains incomplete.
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A quantitative framework for structural interpretation of DMS reactivity

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By Bret Lange, Darren Armstrong, Sanduni Deenalattha, Chris P Jurich
| biorxiv.org
Abstract Dimethyl sulfate (DMS) chemical mapping is widely used for probing RNA structure, with low reactivity interpreted as Watson-Crick (WC) base pairs and high reactivity as unpaired nucleotides. Despite its widespread use, a quantitative understanding of how DMS reactivity relates to specific RNA 3D structural features remains incomplete.
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