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Abstract Crocin, a key bioactive compound derived from saffron (Crocus sativus L.), a traditional Chinese medicinal and edible herb, exhibits renoprotective effects against fibrosis, but the mechanisms remain unclear. Here we show that homeobox D8 (HOXD8) and PGC1-α are downregulated, while reactive oxygen species levels, mitochondrial dysfunction, and fibrosis are increased in kidney fibrosis models.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
