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Xin Li

Verified
Shanghai Shi
As seen in: Nature, Nature Materials, Wiley Online Library, Elsevier, Journal of Manufacturing and Materials Processing, Taylor & Francis Online, Flipboard, Canadian Journal of Infectious Diseases & Medical Microbiology, Journal of the Atmospheric Sciences, Monthly Weather Review, Pakistan Journal of Medical Sciences, Value in Health Journal
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Articles

Precision targeting of tumor-associated macrophages via a 6-substituted pyrrolo[2,3- d ]pyrimidine chimeric molecule for enhanced cancer immunotherapy

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By Yining Zhang, Binghao Guo, Lixiao Guo, Yuqing Wang, Yuwei Zheng, Mengqi Wu, Xueyu Yao, Zeshi Li, Huaying Liu, Zixuan Wang, Mengyuan Lian, Xiaowei Shi, Xin Li Verified, Yi Liu, Zenghui Sun, Haitao Yang, Lei Wang, Ruijuan Xing
| Nature Verified
Abstract Small-molecule PI3Kγ inhibitors can reprogram immunosuppressive myeloid cells but are limited by rapid clearance, lack of cell-type selectivity, and systemic exposure to non-target tissues. Here, we extended a previously developed folate receptor (FR)-directed 6-substituted pyrrolo[2,3-d]pyrimidine ligand to the intracellular delivery of AS-252424.
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Thromboxane A2 receptor signalling amplifies osteoclastogenesis in rheumatoid arthritis through ACSL1 associated mitochondrial oxidative metabolism

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By Liyan Mei, Xin Li Verified, Siyuan Rao, Zifeng Chen, Chenguang Zhan, Xingrui Yan, Mengyang Ma, Peng Zhang, Yu Ho Wen, Xiang Guo, Meiqi Chen, Xiaodong Wu, Kaixin Gao, Haifang Du, Huimin Wang, He Baltimore Sun, Xiumin Chen, Boudewijn M. T. Burgering, Maojie Wang, Runyue Huang, Chunping Bo, Chuangning Li, Bozheng Chen, Junao Wang, Tingkai Zhong, Shuxu Wu
| Nature Verified
Abstract Activated platelets contribute to inflammation in rheumatoid arthritis, but how platelet-derived signals promote bone erosion remains poorly understood. Here we show that thromboxane A2, a major mediator released by activated platelets, promotes the formation of bone-resorbing osteoclasts through the thromboxane A2 receptor.
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Multi-omics analysis identifies ANXA2-associated transcriptomic and splicing networks in osteoblast proliferation and apoptosis

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By Xiuping Li, Jing L. Wang, Wenxiu Zhang, Xin Li Verified, Chen Lei
| Nature Verified
Abstract Osteoporosis (OP), a prevalent metabolic bone disorder characterized by impaired osteoblast function, poses a major health burden worldwide. Annexin A2 (ANXA2), a multifunctional protein with RNA-binding activity, plays a role in OP progression by influencing osteoblast differentiation and apoptosis. However, as an RNA-binding protein (RBP), the genome-wide RNA targets and the molecular mechanisms by which ANXA2 governs osteoblast activity are largely unknown.
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