Sang Jin Rhee

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description ajmgb33056-sup-0001-Tables.docxWord 2007 document , 24.6 KB Table S1: Demographic characteristics of the KOMOGEN-D cohort. Table S2: Disease severity by referral source (Seoul National University Hospital). References , , , et al. 2025. “Trans-Ancestry Genome-Wide Study of Depression Identifies 697 Associations Implicating Cell Types and Pharmacotherapies.” Cell 188, no. 3: 640–652.e9.

Abstract Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970–1990 and followed through 2018, we sought to clarify the degree to which the familial liability to MD is reflected in its clinical features, and the pattern of psychiatric disorders at elevated risk in the siblings of MD probands. The study population included full-siblings of 197,309 MD and matched 197,309 control probands.

Abstract Although depression is an emerging disorder affecting many people worldwide, most genetic studies have been performed in European descent populations. Herein, a genome-wide association study (GWAS) was conducted in Korean population to elucidate the genomic loci associated with depressive symptoms. Two independent cohorts were used as discovery datasets, which consisted of 6474 (1484 cases and 4990 controls) and 1654 (557 cases and 1097 controls) Korean participants, respectively.