Sanheeta Chakrabarty

Abstract Camptothecin, a potent anti-cancer alkaloid originally derived from Camptotheca acuminata, can also be efficiently extracted from the bark of Mappia nimmoniana (J. Graham) Byng & Stull using an innovative green chemistry method, uses an ionic liquid that dissolves cellulose. Camptothecin is the starting material for the commercial semi-synthesis of anticancer drugs topotecan and irinotecan. The described method is helpful for the commercial production of camptothecin.

Prioritization before dereplication, an effective strategy to target new metabolites in whole extract: Ghosalin from Murraya paniculata root Re-discovery of known metabolites is a common challenge in natural product-based drug discovery, and to avoid the rediscovery, dereplication has been adopted for ignoring the known metabolites at the early stage of isolation and characterization. The majority of methods use LCMS to profile extract and ignore the known mass.