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Sanjeevani Choudhery on Muck Rack

Sanjeevani Choudhery

As seen in: BioRxiv
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Articles

Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strains

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By Chidiebere Akusobi, Sanjeevani Choudhery, Bouchra S. Benghomari, Ian Wolf
| BioRxiv
Abstract Mycobacterium abscessus (Mab) is a clinically important pathogen and a highly genetically diverse species due to its large accessory genome. The functional consequence of this diversity remains largely unknown because, to date, functional genomic studies in Mab have been primarily performed on reference strains.
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A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens

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By Sanjeevani Choudhery, Michael DeJesus, Aarthi Srinivasan, Jeremy Michael Rock
| BioRxiv
Abstract An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and mechanisms of action or resistance. The objective is to identify CRISPRi mutants whose relative abundance is suppressed (or enriched) in the presence of a drug when the target protein is depleted, reflecting synergistic behavior.
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A dose-response based model for statistical analysis of chemical genetic interactions in CRISPRi libraries

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By Sanjeevani Choudhery, Michael DeJesus, Aarthi Srinivasan, Jeremy Michael Rock
| BioRxiv
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