Sanjun Shi on Muck Rack

Sanjun Shi

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Articles

Real-time electrical monitoring of enzymatic catalytic dynamics at the single-molecule level

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By Zhimin Fan, Mingdi Xu, Xiaonan Feng, Yulu C. Liu, Ya Hu, Xiaoduo Chen, Guomao Zheng, Bintian Zhang, Zusen Chen, Zhengwen Gong, Sanjun Shi
| Nature Verified
Abstract Monitoring enzyme structural dynamics is essential for elucidating catalytic mechanisms, yet transient conformational fluctuations on microsecond-to-millisecond timescales remain challenging to resolve with conventional techniques. Here, we investigate the catalytic dynamics of cytochrome P450 1A1 (CYP1A1) during benzo[a]pyrene (BaP) metabolism by measuring single-molecule protein conductance.
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