Sankara Rao Patta

SankaraRaoPatta, NareshGantasala, Pradeep P.Desale, SrihariPabbaraja, European Journal of Organic Chemistry2026, 0, e202501043. https://doi.org/10.1002/ejoc.202501043 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data supporting this article have been included as part of the Supporting Information.

A stereoselective synthesis of protected macrocyclic lactone core structure of 13E-disciformycin B was accomplished in a convergent fashion employing commercially available (4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate, tiglic aldehyde and (R)-Roche ester. Key transformations include an Aldol reaction, CBS reduction, Takai olefination, Julia olefination, Nozaki–Hiyama–Kishi (NHK) reaction, and Yamaguchi esterification reaction.

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article. Supporting Information Filename Description ejoc70230-sup-0001-SuppData-S1.pdf2.7 MB Supplementary Material References 1, “Fungal Bioactive Macrolides,” Natural Product Reports 39 (2022): 1591–1621. 2, “Marine Macrolides with Antibacterial and/or Antifungal Activity,” Marine Drugs 17 (2019): 241.