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Santhoshi Krishnan

As seen in: Frontiers, The BMJ
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Articles

Exploring the liver microenvironment following successful therapy for HCV: gene expression profiling and residual T cell infiltration

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By Esteban Arroyave, Santhoshi Krishnan, Jared Zhang, Arvind Rao, Heidi Spratt, Monique Ferguson, Vincent L. Chen, Heather L Stevenson, Omar Saldarriaga, Daniel E. Millian, Timothy G. Wanninger, Daniel Bao, Kellen Henning
| Frontiers
Introduction Although hepatitis C virus (HCV) infection continues to be a global health challenge, with approximately 50 million infected globally and one million new cases each year, the landscape has shifted dramatically in recent years due to the availability of direct-acting antiviral (DAA) therapy (Burki, 2024). By selectively targeting enzymes essential for viral replication, DAAs have achieved cure rates higher than 90% (Oru et al., 2021).
Open in Who Shared Issue with article?

96 Spatial analysis reveals differential immune cell interactions in histologic progression areas of intraductal papillary mucinous neoplasms of the pancreas | Journal for ImmunoTherapy of Cancer

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By Sharia Hernandez, Naohiro Uraoka, Ximing Tang, Santhoshi Krishnan
| The BMJ Verified
Abstract Background Intraductal papillary mucinous neoplasms (IPMN) are heterogeneous cystic lesions of the pancreas and well-known precursors to pancreatic ductal adenocarcinomas (PDAC). Studying the spatial interactions of the immune components of the tumor microenvironment constitutes a significant approach to understanding the progression of these lesions and to identifying a possible opportunity for cancer interception.
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