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Santiswarup Singha

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Articles

Increased yields and biological potency of knob-into-hole-based soluble MHC class II molecules

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By Jesus Blanco, Daniel Parras, Nahir Garabatos, Santiswarup Singha
| Nature Verified
Abstract Assembly of soluble peptide-major histocompatibility complex class II (pMHCII) monomers into multimeric structures enables the detection of antigen-specific CD4+ T cells in biological samples and, in some configurations, their reprogramming in vivo. Unfortunately, current MHCII-αβ chain heterodimerization strategies are typically associated with low production yields and require the use of foreign affinity tags for purification, precluding therapeutic applications in humans.
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