Sanychen Muk on Muck Rack

Sanychen Muk

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Articles

Frustration in the Protein-Protein interface Plays a Central Role in the Cooperativity of PROTAC Ternary Complexes

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By Ning Ma, Supriyo Bhattacharya, Sanychen Muk, Zuzana Jandova
| biorxiv.org
Abstract Targeted protein degradation of a protein of interest (POI) by Proteolysis Targeting Chimeras (PROTACs) is an attractive approach for dealing with formerly undruggable protein targets. PROTACs are heterobifunctional molecules that connect a POI-binding and an E3-ligase (E3) binding motif with a linker.
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