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Articles

Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription.

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By Chaima Azouzi, Katrin Schwank, Saphie Queille, Marta Kwapisz
| biorxiv.org
Abstract The RNA polymerase I (Pol I) enzyme that synthesizes large rRNA precursors, exhibits high rate of pauses during elongation, indicative of a discontinuous process. We show here that Premature Termination of Transcription (PTT) by Pol I is a critical regulatory step limiting rRNA production in vivo. The Pol I mutant, SuperPol (RPA135-F301S), produces 1.5-fold more rRNA than the wild type (WT).
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Ribosomal RNA synthesis by RNA polymerase I is regulated by premature termination of transcription.

|
By Katrin Schwank, Chaima Azouzi, Saphie Queille, Marta Kwapisz
| biorxiv.org
Abstract The RNA polymerase I (Pol I) enzyme that synthesizes large rRNA precursors, exhibits high rate of pauses during elongation, indicative of a discontinuous process. We propose here that Premature Termination of Transcription (PTT) by Pol I is a critical regulatory step limiting rRNA production in vivo. The Pol I mutant, SuperPol (RPA135-F301S), produces 1.5-fold more rRNA than the wild type (WT).
Open in Who Shared Issue with article?
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