Saphira Müller on Muck Rack

Saphira Müller

As seen in: Nature
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Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs - Nature Methods

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By Kim Fabiano Marquart, Nicolas Mathis, Amina Mollaysa, Lucas Kissling, Lukas Schmidheini, Péter István Kulcsár, Ahmed Allam, Mai Matsushita, Toni Cathomen, Saphira Müller
| Nature
Abstract Transposon (IS200/IS605)-encoded TnpB proteins are predecessors of class 2 type V CRISPR effectors and have emerged as one of the most compact genome editors identified thus far. Here, we optimized the design of Deinococcus radiodurans (ISDra2) TnpB for application in mammalian cells (TnpBmax), leading to an average 4.4-fold improvement in editing.
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