Skip To Main Content
Sara Barozzi on Muck Rack

Sara Barozzi

As seen in: Nature, Science Magazine
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Sara

Contact Sara, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Mechano-metabolic feedback connects tissue fluidity to mitochondrial DNA–dependent immunity in breast cancer

|
By Andrea Palamidessi, Emanuela Frittoli, Monica Corada, Emanuele Martini, Leonardo Barzaghi, Chiara Milanese, Galina V. Beznoussenko, Alessandro Lazzarin, Edoardo Bellini, Alexander Mironov, Zeno Lavagnino, Serena Magni, Sara Barozzi, Dario Parazzoli, Valeria Cancila, Patrizia Romani, Melody Di Bona, Renata Zobalova, Stepana Boukalova, Mattia Rediti, Pier G. Mastroberardino, Jiri Neuzil, Marco Foiani, Sirio Dupont, Claudio Tripodo, Giorgio Scita, Laura Tizzoni, Valentina Dall’Olio
| Nature Verified
Abstract Why some tumors respond to immunotherapy (“hot” tumors) while others remain resistant (“cold” tumors) is a central challenge in oncology. Elevated RAB5A-dependent endocytosis drives tissue fluidization during the transition to invasive breast carcinoma, but its immunological consequences are unclear. Here we show that RAB5A-driven fluidization induces a mechano-metabolic stress response that disrupts the AMPK–AKAP1–DRP1 mitochondrial fission pathway, causing mitochondrial elongation.
Open in Who Shared Issue with article?
See all 1 articles