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Sara Costa-Pinto

As seen in: Wiley Online Library, BioRxiv
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Articles

Adenosine receptors are the on‐and‐off switch of astrocytic cannabinoid type 1 (CB1) receptor effect upon synaptic plasticity in the medial prefrontal cortex

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By Oksana K. Savchak, Sara Costa-Pinto, Joana Gomes, Joana Gonçalves-Ribeiro
| Wiley Online Library Verified
1 INTRODUCTION Astrocytes tightly and dynamically interact with synapses having a critical role in synaptic information processing (Araque et al., 1999; Araque et al., 2014; Durkee & Alfonso, 2019; Guerra-Gomes et al., 2018; Perea et al., 2009; Perea & Araque, 2005), ultimately playing a critical function in cognitive (Kofuji & Araque, 2021), anxiety (Cho et al., 2022) and depressive-like behavior (Banasr & Duman, 2008).
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Increasing the vitamin C transporter SVCT2 in microglia improves synaptic plasticity and restrains memory impairments in Alzheimer's disease models

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By Ana Pacheco, Tiago Almeida, Sara Costa-Pinto, Joana Tedim-Moreira
| BioRxiv
Abstract Alzheimer's Disease (AD) is characterized by progressive cognitive decline and synaptic dysfunction, often associated with amyloid-beta accumulation and microglial alterations. Here, we investigate the role of the Sodium-dependent Vitamin C Transporter 2 (SVCT2) in microglia to modulate AD-like pathology in mice.
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