Sara Mercurio

I, like many, find myself returning to this poem every spring. It depicts a narrator who, while enroute to London, watches several weddings from the window of his train. This poem captures the familiar surprise of springtime. It is easy to become totally enthralled by winter, struggling through the endless cold; then, suddenly, it is spring, and there are buds on the trees. While our heads were down, time has moved forward.

1. Introduction SOX18, and the closely related SOX7 and SOX17 proteins, belong to the SOXF group of Sry-related HMG-box transcription factors [1], which play various roles in cardiovascular and lymphatic development [2]. Mutations in SOX18 underlie dominant and recessive forms of hypotrichosis–lymphedema–telangiectasia syndrome (HLTS) [3], combining defects in hair/eyelashes/eyebrows with lymphatic dysfunction, cutaneous red stains and, in some cases, renal failure (HLTRS) [4].

Abstract : The SOX2 transcription factor is a key regulator of nervous system development, and its mutation in humans leads to a rare disease characterized by severe eye defects, cognitive defects, hearing defects, abnormalities of the CNS and motor control problems. SOX2 has an essential role in neural stem cell maintenance in specific regions of the brain, and it is one of the master genes required for the generation of induced pluripotent stem cells.