Sara N Bramlett

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CONFLICT OF INTEREST STATEMENT The authors declare that they have no conflict of interest. REFERENCES (1999). Feature article: Comparative development of the mammalian isocortex and the reptilian dorsal ventricular ridge. Evolutionary considerations. Cerebral Cortex, 9(8), 783–791. https://doi.org/10.1093/cercor/9.8.783 , , , , , , , , , , , , , , , , , , , & (2018). Kynurenic acid and Gpr35 regulate adipose tissue energy homeostasis and inflammation. Cell Metabolism, 27(2), 378–392.e5.

Abstract Addictive drugs hijack the neuronal mechanisms of learning and memory in motivation and emotion processing circuits to reinforce their own use. Regulator of G-protein Signaling 14 (RGS14) is a natural suppressor of post-synaptic plasticity underlying learning and memory in the hippocampus. The present study used immunofluorescence and RGS14 knockout mice to assess the role of RGS14 in behavioral plasticity and reward learning induced by chronic cocaine in emotional-motivational circuits.