Sarah Barman

Key Words CLSA stroke arteriole venule sex INTRODUCTION Stroke occurs when a cerebral infarction or hemorrhage disrupts blood flow and subsequently causes acute damage to the brain tissue.1 It is the second leading cause of death globally and the third leading contributor to disability, often resulting in cognitive or motor impairments.2 Most strokes stem from systemic vascular etiologies such as small vessel disease, large artery disease, or cardio-embolism, and well-established risk factors...

Materials and methods UKB is a prospective cohort study for which baseline biomedical and physical assessments were carried out 2006–2013, in 502 682 adults aged 40–69 years recruited from 22 UK centres.23 Ocular assessments occurred during the latter phase (2009–2013; seven centres) and included visual acuity, autorefraction, digital fundus photography with the Topcon 3D-OCT 1000 Mark 2.20 Non-mydriatic 45° digital colour images, centred on the fovea were available for 88 052 participants.