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Highlights • E93 is required to terminate MB neurogenesis in Drosophila • E93 downregulates PI3K levels to activate MB neuroblast autophagy • E93 is a late-acting temporal factor, regulated by intrinsic Imp and Syp • Extrinsic steroid hormone signaling boosts E93 levels for neurogenesis termination Summary Most neurogenesis occurs during development, driven by the cell divisions of neural stem cells (NSCs).
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