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Sarah G Staedke on Muck Rack

Sarah G Staedke

Kisumu
As seen in: The Lancet
Clinical epidemiologist specializing in malaria, infectious diseases, global health. Based in Kenya. @LSTM @KEMRI_Kenya
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Articles

Targeting malaria control to schoolchildren

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By Sarah G Staedke, Catherine Maiteki-Sebuguzi
| The Lancet Verified
The burden of malaria in school-aged children has been underappreciated. 1 Nankabirwa J Brooker SJ Clarke SE et al. Malaria in school-age children in Africa: an increasingly important challenge. Typically, by the time African children are old enough to attend school, they have acquired antimalarial immunity through repeated exposure and can tolerate malaria infections without developing severe symptoms. 2 Rodriguez-Barraquer I Arinaitwe E Jagannathan P et al.
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Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign

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By Sarah G Staedke, Grant Dorsey, Samuel Gonahasa
| The Lancet Verified
Summary Background Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda's national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors.
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LLIN Evaluation in Uganda Project (LLINEUP) - Impact of long-lasting insecticidal nets with, and without, piperonyl butoxide on malaria indicators in Uganda: study protocol for a cluster-randomised trial | Trials | Full Text

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By Sarah G Staedke, Moses Kamya, Grant Dorsey, Catherine Maiteki-Sebuguzi
| Biomed Central (BMC)
Received: 2 November 2018 Accepted: 24 April 2019 Published: 3 June 2019 Abstract Background Long-lasting insecticidal nets (LLINs) are a key malaria control intervention, but their effectiveness is threatened by resistance to pyrethroid insecticides. Some new LLINs combine pyrethroids with piperonyl butoxide (PBO), a synergist that can overcome P450-based metabolic resistance to pyrethroids in mosquitoes.
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