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Sarah Knapp on Muck Rack

Sarah Knapp

Wellington
As seen in: Nature, MDPI, Taylor & Francis Online, Lonely Planet, Outside Magazine, Benzinga, Travel + Leisure, BioRxiv, Climbing Magazine, JD Supra and

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Articles

Transferrin receptor 1 shedding by the pro-inflammatory iRhom–ADAM17 complex and ADAM10 regulates cellular iron uptake and ferroptosis

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By Yan Yu, Sarah Knapp, Neele Schumacher, Aaron Babendreyer, Andreas Ludwig, Stefan Düsterhöft, Katharina Schun, Cindy Rinkens, Daniel Mehling, Carolin Peschke, Friederike Sonnabend, Alessa Pabst, Laura Charlier
| Nature Verified
Abstract Iron homeostasis is a tightly regulated mechanism, wherein the uptake, transport, storage and export of iron are stringently controlled. Dysregulation and excessive iron uptake lead to iron-dependent programmed cell death called ferroptosis, a promising future cancer therapy target. Cellular iron uptake is limited by the surface presence of membrane-bound transferrin receptor 1 (TfR1). Soluble TfR1 is used as a major clinical marker to differentiate anemia types.
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Screening assay to monitor mono-ADP-ribosylhydrolase activity of viral macrodomains in cells

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By Sarah Knapp, Verena Weber, Tanner Wright, Lukas Hauser, Sarah Krieg, Dana Ferraris, Stefan Knapp, Andreas G. Ladurner, Giulia Rossetti, Bernhard Lüscher, Patricia Korn, Maud Verheirstraeten, Ani Sabcheva, Lea Herkens, Lea Hirschen, Alexandra Golzmann, Barbara Lippok
| Nature Verified
Abstract Mono-ADP-ribosylation, a modification of both proteins and nucleic acids, is implicated in innate immunity. Intracellularly, this modification is catalyzed by PARP enzymes, some induced in response to interferons. Mono-ADP-ribosylation is reversed by hydrolases including proteins with macrodomains, which are conserved across all kingdoms of life.
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Chaplain care for health care colleagues: a scoping review

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By Sarah Knapp, Benjamin Schaefer, Timothy J. Usset, R. Greg Stratton
| Taylor & Francis Online
Abstract In addition to supporting patients and their loved ones at critical times, chaplains have long understood that caring for their health care colleagues is an important part of their practice. The Covid-19 pandemic prompted conversations among chaplains about how best to address the stress they were observing in health care workers. Our team conducted a scoping review in PubMed and CINAHL of peer reviewed literature describing chaplaincy care for health care workers.
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