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Articles

Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer’s disease

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By Aysegul Aydin, Pranav Manoj, Faiza Ramadan, Sarah Rajan, Elias Youssef, Elizabeth Torres, Kasia M. Bieszczad
| Nature Verified
Abstract Hearing is the largest modifiable mid-life risk factor for Alzheimer’s disease (AD), yet its link to dementia remains unclear. We identified a neurophysiological biomarker of AD risk using the non-invasive, rapidly acquired, and clinically translatable auditory brainstem response (ABR) in normal hearing knock-in rats (Swedish familial AD risk variant to Amyloid precursor protein, AppS; male and female). Human ABRs have been proposed as a biomarker for AD and related dementias.
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