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Sarah V. Barrass on Muck Rack

Sarah V. Barrass

As seen in: Nature, BioRxiv
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Articles

Ultrathin liquid cells for microsecond time-resolved cryo-EM - Nature Communications

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By Wyatt A. Curtis, Constantin Krüger, Sarah V. Barrass, Marcel Drabbels, Jakub Wenz
| Nature Verified
Abstract Microsecond time-resolved cryo-electron microscopy promises to significantly advance our understanding of protein function by rendering cryo-electron microscopy (cryo-EM) fast enough to observe proteins at work. This emerging technique involves flash melting a cryo sample with a laser beam to provide a brief time window during which dynamics are initiated. When the laser is switched off, the sample revitrifies, arresting the proteins in their transient configurations.
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Laser flash melting cryo-EM samples to overcome preferred orientation - Nature Methods

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By Monique S. Straub, Sarah V. Barrass, Jakub Hrubý, Marcel Drabbels
| Nature Verified
Abstract Sample preparation remains a bottleneck for protein structure determination by cryo-electron microscopy. A frequently encountered issue is that proteins adsorb to the air–water interface of the sample in a limited number of orientations. This makes it challenging to obtain high-resolution reconstructions, or may even cause projects to fail altogether.
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Cryo-EM Sample Preparation with Soft-Landing and Laser Flash Melting

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By Sarah V. Barrass, Tim K. Esser, Nathan J. Mowry, Lukas Eriksson
| BioRxiv
Abstract The preparation of cryo-EM samples by soft-landing mass spectrometry promises to significantly simplify sample optimization, which has remained an important bottleneck in single-particle cryoelectron microscopy (cryo-EM). However, only compacted configurations are observed after softlanding since the proteins are dehydrated in the process.
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