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Saranathan Rajagopalan on Muck Rack

Saranathan Rajagopalan

As seen in: BioRxiv
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Articles

Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

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By Benjamin N. Koleske, Saranathan Rajagopalan, Shichun Lun, Courtney Schill
| BioRxiv
Abstract The ESX-5 secretion system, uniquely found in slow-growing mycobacteria, is predicted to secrete over 150 proteins across the inner membrane of Mycobacterium tuberculosis (M.tb). Although many of these substrates are believed to promote M.tb virulence, most remain poorly characterized. Here, we use a complete locus deletion strain of ESX-5 in M.tb to examine the molecular changes caused by a broad loss in ESX-5 secretory substrates.
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Intravenous Immunization with Triple Auxotrophs of Mycobacterium tuberculosis: A novel vaccine strategy against tuberculosis

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By Catherine Vilcheze, Saranathan Rajagopalan, William Jacobs, Albert Einstein College
| BioRxiv
Abstract Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading infectious cause of mortality worldwide despite widespread use of the BCG vaccine and the availability of sterilizing pharmacopoeia. Recent research indicates that the intravenous administration of BCG confers sterilizing immunity against Mtb pulmonary challenge in non-human primates.
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The SapM phosphatase arrests phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG

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By William R. Jacobs, Miriam Braunstein, Christian Xander, Saranathan Rajagopalan
| BioRxiv
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