Skip To Main Content
Sarra Ryan on Muck Rack

Sarra Ryan

As seen in: Nature, NewsBreak
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Sarra

Contact Sarra, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

DUX4-rearranged B-ALL: deciphering a biological and clinical conundrum - Leukemia

|
By Anthony V Moorman, Sarra Ryan
| Nature Verified
Abstract The DUX4 gene, located within repetitive subtelomeric arrays on chromosomes 4 and 10, plays a critical role in early embryogenesis and has been implicated in several human diseases, including facioscapulohumeral muscular dystrophy (FSHD) and cancer. In B-cell acute lymphoblastic leukemia (B-ALL), DUX4 rearrangements (DUX4-r) define a distinct genomic subtype affecting 5–10% of cases, which is more frequent among older children and teenagers.
Open in Who Shared Issue with article?

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia

|
By Sarra Ryan
| NewsBreak
Our new Privacy Policy will go into effect on January 1st, 2023. Follow the link to read our updated Privacy Policy
Open in Who Shared View Duplicates (697) Issue with article?

SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain

|
By Paul Sinclair, Sarra Ryan, Matthew Bashton, Shaun Hollern
| Nature Verified
Abstract In more than 30% of B-cell precursor acute lymphoblastic leukaemia (B-ALL), chromosome 21 sequence is overrepresented through aneuploidy or structural rearrangements, exemplified by intrachromosomal amplification of chromosome 21 (iAMP21). Although frequent, the mechanisms by which these abnormalities promote B-ALL remain obscure.
Open in Who Shared Issue with article?
See all 3 articles