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In healthy individuals, Cytomegalovirus (CMV) infections are controlled by CMV-specific cell-mediated immunity (CMI). However, functional impairment of the CMI in immunocompromized individuals can lead to uncontrolled CMV-replication. Thus, monitoring CMV-specific CMI is highly relevant for the prognosis of CMV-associated diseases. Here we show the optimization and technical validation of a monitoring tool for the determination of CMV-specific CMI.
Background Cytomegalovirus (CMV) is the most common congenital viral infection. Mother-to child transmission (MTCT) can cause severe disability of the child. Intact CMV-specific cell-mediated immunity (CMI) has been shown to prevent uncontrolled replication in healthy individuals. In this study we aim to determine whether CMV-specific CMI is impaired in pregnant women, thus increasing the overall risk for active CMV replication and transmission.
Objective Monitoring the cellular immunity for Cytomegalovirus (CMV) in organ transplant recipients is a promising tool to support prevention strategies for posttransplant CMV infection or reactivation. Commercially available in vitro test systems differ substantially in their capacity to stimulate subpopulations of T-lymphocytes. We compared two assays for CMV immune monitoring in respect of their clinical practicability and significance.
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