Saskia Catherina Stein on Muck Rack

Saskia Catherina Stein

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Articles

Toward Anti‐Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma‐Associated Herpesvirus Latency‐Associated Nuclear Antigen

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By Aylin Berwanger, Sarah Brandner, Andreas Martin Kany, Saskia Catherina Stein
| Wiley Online Library Verified
1 Introduction Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human gamma-herpesvirus 8 (HHV-8), is a member of the herpesvirus family.[1] It plays a significant role in the development of Kaposi's sarcoma, a cancer commonly observed in individuals with AIDS.[2] KSHV exhibits a dual life cycle, characterized by latent and lytic phases.[3] During latent infection, KSHV persists within host cells, maintaining its genome as an extrachromosomal episome.[1] The latency-associated...
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