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Saso Cemerski on Muck Rack

Saso Cemerski

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Articles

Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8 + T cells

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By Jesusa Capera, María Navarro-Pérez, Ashwin Jainarayanan, Salvatore Valvo, Lina Chen, Panyu Fei, Sarah Flannery, Roman Fischer, Simon Low, Steven Quayle, Raymond J. Moniz, Anish Suri, Michael L. Dustin, Saso Cemerski
| Nature Verified
Abstract Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. Following antigen recognition, IL2 receptor (IL2R) signaling polarizes towards the immunological synapse (IS). However, how IL2 function is integrated during earlier antigen-dependent T cell synapses remains unknown.
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