Sathnur Pushpakumar

2. Materials and Methods 2.1. Animal Groups and DATS Treatment C57BL/6J wild type (WT, Stock no.: 000664) mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA) and bred in-house, housed in a temperature- and light-controlled environment at the University of Louisville animal facility. Female mice aged 75–78 weeks were used in the study.

1 INTRODUCTION Interoception is a term used to describe the process by which an organism perceives, interprets, and integrates internal physiological signals originating from within the body. These signals convey information about various aspects of bodily functions, such as heart rate, respiration, blood pressure, hunger, thirst, temperature, and visceral sensations.

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