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Satisk K Tadi on Muck Rack

Satisk K Tadi

As seen in: BioRxiv
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Articles

Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays

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By Davide Monteferrario, Marion David, Satisk K Tadi
| BioRxiv
Abstract Gene silencing without gene editing holds great potential for the development of safe therapeutic applications. Here, we describe a novel strategy to concomitantly repress multiple genes using zinc finger proteins fused to Kruppel-Associated Box repression domains (ZF-Rs). This was achieved via the optimization of a lentiviral system tailored for the delivery of ZF-Rs in hematopoietic cells.
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