Satya Dev Polisetty on Muck Rack

Satya Dev Polisetty

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Articles

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans

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By Satya Dev Polisetty, Krishna Bhat, Kuladeep Das, Ivan Clark
| biorxiv.org
Abstract During chromosome segregation, the spindle assembly checkpoint (SAC) detects errors in kinetochore-microtubule attachments. Timely activation and maintenance of the SAC until defects are corrected is essential for genome stability. Here, we show that shugoshin (Sgo1), a conserved tension-sensing protein, ensures the maintenance of SAC signals in response to unattached kinetochores during mitosis in a basidiomycete budding yeast Cryptococcus neoformans.
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Shugoshin maintains mitotic arrest in response to improper kinetochore-microtubule interactions independent of the Bub1-pH2A axis

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By Satya Dev Polisetty, Krishna Bhat, Ivan Clark, Kevin Hardwick
| biorxiv.org
Abstract During chromosome segregation, the spindle assembly checkpoint (SAC) detects errors in kinetochore-microtubule attachments. Timely activation and maintenance of the SAC until defects are corrected is essential for genome stability. Here, we show that SGO1 codes for shugoshin, a tension-sensing protein, that ensures the maintenance of SAC signals in response to unattached kinetochores during mitosis in a basidiomycete budding yeast Cryptococcus neoformans.
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Functional Plasticity in Chromosome-Microtubule Coupling on the Evolutionary Time Scale

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By Arti B. Dumbrepatil, Sundar Ram Sankaranarayanan, Satya Dev Polisetty, Kuladeep Das
| biorxiv.org
Abstract The Dam1 complex is essential for mitotic progression across evolutionarily divergent fungi. Upon analyzing amino acid (aa) sequences of Dad2, a Dam1 complex subunit, we identified a conserved 10-aa-long Dad2 signature sequence (DSS). An arginine residue (R126) in the DSS is essential for viability in Saccharomyces cerevisiae that possesses point centromeres.
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