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Saverio La Francesca on Muck Rack

Saverio La Francesca

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Articles

Production and transplantation of bioengineered lung into a large-animal model

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By Joan E. Nichols, Saverio La Francesca, Jean A. Niles, Stephanie P. Vega
| Science Magazine Verified
Lungs are complex organs to engineer: They contain multiple specialized cell types in extracellular matrix with a unique architecture that must maintain compliance during respiration. Nichols et al. tackled the challenges of vascular perfusion, recellularization, and engraftment of tissue-engineered lungs in a clinically relevant pig model. Nanoparticle and hydrogel delivery of growth factors promoted cell adhesion to whole decellularized pig lung scaffolds.
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