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Crystal Structure of an i‐Motif from the HRAS Oncogene Promoter

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By Kevin Li, Deondre Jordan, Linda Lin, Sawyer Mccarthy
| Wiley Online Library Verified
Graphical Abstract The structure of a biologically relevant i-motif from the HRAS oncogene was solved to 1.8 Å resolution. The structure is a dimer of two i-motifs formed by six C−C+ pairs. The structure contains 20 base pairs, of which only two are canonical. The extensive network of capping and connecting interactions is unprecedented and suggests that auxiliary interactions are essential for i-motif stability in vivo.
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