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Sayantee Sen

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Minimized sample consumption for time-resolved serial crystallography applied to the redox cycle of human NQO1 - Communications Chemistry

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By Diandra Doppler, Abhik Manna, Hung Le, Hùng Lê, Mukul Sonker, Gihan Ketawala, Romain Letrun, Katerina Dorner, Raphael de Wijn, Johan Bielecki, Huijong Han, Chan Kim, Adam Round, Abhisakh Sarma, Tokushi Sato, Christina Schmidt, Mohammad Ghazi Vakili, Richard Bean, Joachim Schulz, Raimund Fromme, Milagros Medina, Thomas Grant, Petra Fromme, Richard A. Kirian, Sabine Botha, José Martín-García, Sayantee Sen
| Nature Verified
Abstract Sample consumption for serial femtosecond crystallography with X-ray free electron lasers remains a major limitation preventing broader use in macromolecular crystallography. This drawback is exacerbated in time-resolved (TR) experiments, where the amount of sample required per reaction time point is multiplied by the number of time points investigated.
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