Sayit Mahmut Erdogan on Muck Rack

Sayit Mahmut Erdogan

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Articles

Epitope-selective vaccine designs to elicit protective antibodies against the Plasmodium falciparum circumsporozoite protein

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By Mohammad mehdi Naghizadeh, Yevel Flores-Garcia, Gregory Martin, Ebenezer Addo Ofori, Jordan L. Plieskatt, Fabien Cannac, Randall S. MacGill, Morten Nielsen, Emily Locke, C. Richter King, Kazutoyo Miura, Ashley Birkett, Adam F. Sander, Kristin Skogstrand, Lea Barfod, Nis Borbye-Lorenzen, Ian Wilson, Andrew Ward, Fidel Zavala, Michael Theisen, Reem Moskovitz, Sayit Mahmut Erdogan, Lorraine A. Soisson, Berenice Salgado-Jimenez
| Nature Verified
Abstract P. falciparum (Pf) malaria is a major cause of morbidity and mortality in sub-Saharan Africa. Recently introduced malaria vaccines, RTS,S/AS01 and R21/Matrix-M, are effective in preventing infection, but their efficacy declines over time. To address this challenge, next-generation vaccine candidates have been designed to improve the functional immunogenicity to the circumsporozoite protein (PfCSP). In this study, we tested multiple hypotheses for improved vaccine design.
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