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Research Articles, Neurobiology of Disease Tanusree Sen, Pampa Saha, Rajaneesh Gupta, Lesley M. Foley, Tong Jiang, Olena S. Abakumova, Kevin T.

Amyloid-β (Aβ), tau aggregates, and nitrosative stress all contribute to the synaptic dysfunction and neurodegeneration associated with the pathology of Alzheimer’s disease. Sen et al. found that the three are functionally linked; Aβ-induced tau acetylation and aggregation by stimulating the enzyme that produces nitric oxide (NO).

Subsequently, we assessed the duration of the treatment effect among a random sample of those who completed the outcome assessment tool by measuring physician performance again six months after the completion of the initial trial protocol (primary six month reassessment outcome). We hypothesized that physicians exposed to game based education during the initial trial would continue to under-triage fewer patients on the simulation than physicians exposed to the didactic program.