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Schuyler M. Melore on Muck Rack

Schuyler M. Melore

As seen in: Nature, BioRxiv
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Articles

dHyperCas12a enables multiplexed CRISPRi screens - Nature Communications

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By Schuyler M. Melore, Marisa C. Hamilton, Charles A Gersbach, Timothy E. Reddy
| Nature Verified
Abstract Interactions between genes or cis-regulatory elements (CREs) underlie many biological processes. High-throughput CRISPR screens have allowed researchers to assess the impact of activation or repression of gene and regulatory elements on many phenotypes. However, assessment of interactions between those genes or elements remains limited.
Open in Who Shared Issue with article?

HyperCas12a enables multiplexed CRISPRi screens

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By Schuyler M. Melore, Christian Amador, Marisa C. Hamilton, Charles A Gersbach
| BioRxiv
Abstract Interactions between multiple genes or cis-regulatory elements (CREs) underlie a wide range of biological processes in both health and disease. High-throughput screens using dCas9 fused to epigenome editing domains have allowed researchers to assess the impact of activation or repression of both coding and non-coding genomic regions on a phenotype of interest, but assessment of genetic interactions between those elements has been limited to pairs.
Open in Who Shared Issue with article?

HyperCas12a enables highly-multiplexed epigenome editing screens

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By Schuyler M. Melore, Marisa C. Hamilton, Timothy E. Reddy
| BioRxiv
Abstract Interactions between multiple genes or cis-regulatory elements (CREs) underlie a wide range of biological processes in both health and disease. High-throughput screens using dCas9 fused to epigenome editing domains have allowed researchers to assess the impact of activation or repression of both coding and non-coding genomic regions on a phenotype of interest, but assessment of genetic interactions between those elements has been limited to pairs.
Open in Who Shared Issue with article?
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