Scott Biering
United States
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Scott Biering
Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Puerta-Guardo H, Biering SB, Castillo-Rojas B, DiBiasio-White MJ, Lo NTN, Espinosa DA, et al. (2025) Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination. PLoS Pathog 21(12): e1013811. https://doi.org/10.1371/journal.ppat.1013811 Editor: Margo A.
Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination
Abstract The Flaviviridae are a family of viruses that include the important arthropod-borne human pathogens dengue virus (DENV), West Nile virus, Zika virus, Japanese encephalitis virus, and yellow fever virus. Flavivirus nonstructural protein 1 (NS1) is essential for virus replication but is also secreted from virus-infected cells.
"Genome-Wide Bidirectional Crispr Screens Identify Mucins as Host Facto" by Scott B Biering, Sylvia A Sarnik et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19).
Infant antibody and B-cell responses following confirmed pediatric GII.17 norovirus infections functionally distinguish GII.17 genetic clusters
Introduction Human norovirus (norovirus) is a leading causative agent of epidemic and endemic acute gastroenteritis (AGE) worldwide (1, 2). There are an estimated 686 million norovirus cases annually across the globe with 200 million cases in children under 5 years of age, leading to about 50,000 child deaths (3). In children, symptoms include fever, body aches, diarrhea, and vomiting that can lead to dehydration and malnutrition (4–6).
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling - Nature Communications
Abstract Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of vascular leak are unclear.
An intranasal ASO therapeutic targeting SARS-CoV-2 - Nature Communications
Abstract The COVID-19 pandemic is exacting an increasing toll worldwide, with new SARS-CoV-2 variants emerging that exhibit higher infectivity rates and that may partially evade vaccine and antibody immunity. Rapid deployment of non-invasive therapeutic avenues capable of preventing infection by all SARS-CoV-2 variants could complement current vaccination efforts and help turn the tide on the COVID-19 pandemic.
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection - Nature Genetics
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2–host interactions and the progression of Coronavirus disease 2019 (COVID-19).
Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction
Two antibodies against flaviviruses Flaviviruses are a group of RNA viruses that include the human pathogens dengue virus, Zika virus, and West Nile virus. The envelope protein (E) on the virus surface has been the target of vaccine development, but problems have arisen with antibodies against E, leading to enhanced infection. Now, Modhiran et al. and Biering et al.
Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction
Scott B. Biering https://orcid.org/0000-0003-1991-629X, David L. Akey https://orcid.org/0000-0002-5687-540X, Marcus P. Wong https://orcid.org/0000-0001-6554-2976, W. Clay Brown, Nicholas T. N. Lo, Henry Puerta-Guardo https://orcid.org/0000-0003-3050-4480, Francielle Tramontini Gomes de Sousa https://orcid.org/0000-0002-3168-0278, … Show All … , Chunling Wang, Jamie R. Konwerski https://orcid.org/0000-0001-9691-0663, Diego A. Espinosa https://orcid.org/0000-0002-4364-5031, Nicholas J.
CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner
Virus-Cell Interactions Kevin Furlong, Scott B. Biering, Jayoung Choi, Craig B. Wilen, Robert C. Orchard, Christiane E. Wobus, Christopher A. Nelson, Daved H. Fremont, Megan T. Baldridge, Glenn Randall, Seungmin Hwang Bryan R. G. Williams, Editor DOI: 10.1128/JVI.00837-20 ABSTRACT Human norovirus is the leading cause of gastroenteritis worldwide, yet basic questions about its life cycle remain unanswered due to an historical lack of robust experimental systems.
CD300LF polymorphisms of inbred mouse strains confer resistance to murine norovirus infection in a cell type-dependent manner
Virus-Cell Interactions Kevin Furlong, Scott B. Biering, Jayoung Choi, Craig B. Wilen, Robert C. Orchard, Christiane E. Wobus, Christopher A. Nelson, Daved H. Fremont, Megan T. Baldridge, Glenn Randall, Seungmin Hwang DOI: 10.1128/JVI.00837-20 ABSTRACT Human norovirus is the leading cause of gastroenteritis worldwide, yet basic questions about its life cycle remain unanswered due to an historical lack of robust experimental systems.
Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2
Note This article is made available via the ACS COVID-19 subset for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism
Highlights • Flavivirus NS1 proteins induce endothelial dysfunction in a tissue-specific manner • Tissue tropism of 5 NS1 proteins is partly determined by endothelial cell binding • NS1-induced endothelial dysfunction is mediated by endothelial glycocalyx disruption • Flavivirus NS1 proteins induce tissue-specific leak in mice mirroring viral tropism Summary Flaviviruses cause systemic or neurotropic-encephalitic pathology in humans.
Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens
Intestinal reovirus infection can trigger T helper 1 (T 1) immunity to dietary antigen, raising the question of whether other viruses can have a similar impact. Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces T 1 immunity to dietary antigen. This property of CW3 is dependent on its major capsid protein, a virulence determinant.
Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases
Publication HistoryPublished: June 29, 2017Accepted: June 8, 2017; Received in revised form: April 14, 2017; Received: January 10, 2017;
Interferon-gamma inducible GTPases disrupt viral replication complex upon their targeting by the LC3 conjugation system of autophagy
Viruses with a single strand (+) sense RNA genome replicate within vacuole-like structures in cytoplasm, called replication complex (RC). RC is made through reorganization of cellular organelle membranes, and it provides a favorable microenvironment for the viruses to replicate. How the host immune system counteracts viral RCs has been obscure. Recently, we found that interferon-gamma (IFNγ) inhibits the replication of murine norovirus (MNV) at the stage of RC formation.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Scott
Contact Scott, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack