Scott Smith

Research Article HEALTH AND MEDICINE INTRODUCTION Bone is a metabolically active tissue undergoing constant modeling and remodeling to repair microdamage and adapt its structure to mechanical forces (1, 2), requiring intricate coordination between bone-resorbing osteoclasts and bone-forming osteoblasts (3, 4). The reversal phase serves as a critical transitional stage, mediating the coupling of these two cell types to maintain a healthy bone balance.