Sean Barber

Angiomatoid fibrous histiocytoma (AFH) is a poorly understood rare soft tissue neoplasm. To our understanding, this is the first reported case of a confirmed primary intracranial lesion with spinal metastasis. AFH is diagnostically challenging as it lacks a specific immunoprofile, making immunohistochemical studies supportive rather than diagnostic.

We applaud Jean-Yves Blay and colleagues 1 Blay JY Chevret S Le Cesne A et al. Pembrolizumab in patients with rare and ultra-rare sarcomas (AcSé Pembrolizumab): analysis of a subgroup from a non-randomised, open-label, phase 2, basket trial. for their Article published in The Lancet Oncology , which provides further evidence that immune checkpoint inhibitors are most effective in alveolar soft part sarcoma 2 Somaiah N Conley AP Parra ER et al.