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Articles

cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis - Nature Communications

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By Hideo Negishi, Yusuke Wada, Yoshitaka Shirasaki, Tomoya Hayashi, Yuji Kubota, Tomio Iwasaki, Mina Kurosawa, Tatsuma Ban, Daisuke Muto, Yusuke Suenaga, Taichi Kojima, Yuzuki Matsuda, Sean Irish, Kosuke Dodo, Toru Suzuki, Mai Yamagishi, Burcu Temizoz, Atsushi Yoshimori, Chisato Kanai, Yoji Nagasaki, Masaki Ohmuraya, Tomohiko Tamura, Atsushi Iwama, Toshifumi Inada, Etsushi Kuroda, Kouji Kobiyama, Noriko Toyama-Sorimachi, Mutsuhiro Takekawa, Cevayir Coban, Ken Ishii
| Nature Verified
Abstract Self-DNA triggers cGAS-STING-mediated type I interferon (IFN-I) to induce both protective and pathogenic immune responses; however, how self-DNA activates the cytosolic cGAS-STING pathway remains unclear. Here we show that the cGAS/STING/IFN-I axis is activated by self-DNA via a process termed ‘nucleocytosis’, in which nuclear DNA is extracted from dying cells by macrophages.
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Just Stop Oil activists guilty of public nuisance over Dartford Crossing protest

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By Sean Irish
| Inkl
He said they ascended to a point close to 200ft above the road and unfurled a “giant Just Stop Oil banner” and “rigged up hammocks and stayed there”. The Queen Elizabeth II Bridge, which links the M25 in Essex and Kent, was closed from 4am on October 17 last year to 9pm the following day, the prosecutor said. “This closure caused gridlock for miles around throughout that period, which we say was the point,” said Mr King.
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