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Articles by Sean X. Gu
Facilitate AI-Human Architectural Thinking
Architectural thinking or modeling will only be effective when it involves a landscape, decisional, and structural view. People talk a lot about systems thinking, but to ensure a viable architectural model, systems thinking must approach it from the three pillars of thinking. AI-powered architectural thinking or modeling also requires these three pillars of thinking.
Beyond Code System and AI Capability
ARCHITECTURAL ANALYSIS & MODELING Tackling the limitations of AI-assisted systems analytics For an enterprise solution system, technical debt is a significant problem. However, what lies behind is a multitude of architectural issues. Developers working on large and complex solutions often find themselves restricted in their responsibility area without a holistic view of the enterprise solution architecture (ESA).
Blending AI and Non-AI Systems Is the Real First Step Your Business Should Take.
AI, Algorithms? All of this is an Afterthought — Blending AI and Non-AI Systems Is the Real First Step Your Business Should Take In today’s AI-populated world, conversations about AI architecture often zoom in on AI apps, agents, or integrations, overlooking the bigger picture: enterprise solution architecture (ESA). ESA bridges the gap between enterprise-wide goals and specific solution designs.
Ineffective IT Architecture? Try the Viable ESA Model
Sean Gu · Follow Published in Enterprise Solution Architecture · 5 min read · -- In the IT world, we often see that many well-crafted architectures fail to meet expectations. The reasons are many, but a common one is the lack of a clear model for viability. An Enterprise Solution Architecture (ESA) specifies a five-area model that covers key considerations in an enterprise environment in terms of common architectures such as enterprise architecture and software architecture.
Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency
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Keywords endothelial cell human induced pluripotent stem cell single ventricle congenital heart defect tissue-engineered vascular conduit flow bioreactor shear stress training Get full text access Log in, subscribe or purchase for full access. References 1. de Leval, M.R. ∙ Deanfield, J.E. Four decades of Fontan palliation Nat. Rev. Cardiol. 2010; 7:520-527 2. Hoffman, J.I.E. ∙ Kaplan, S. The incidence of congenital heart disease J. Am. Coll. Cardiol. 2002; 39:1890-1900 3. Samánek, M.
By Jinkyu Park, Muhammad Riaz, Lingfeng Qin, Wei Zhang, Saba Fooladi, Mehmet Kural, Xin Li, Zhen Xu, Juan Wang, Kimihiko Banno, Sean X. Gu, Yifan Yuan, Christopher Anderson, Matthew Ellis, Jiahui Zhou, Jiesi Luo, Xiangyu Shi, Jae Hun Shin, Yufeng Liu, Seoyeon Lee, Mervin Yoder, Robert Elder, Michael Mak, Stephanie L. Thorn, Albert J. Sinusas, Peter Gruber, John Hwa, George Tellides, Laura E. Niklason, Yibing Qyang, Luke Batty, Hangqi Luo
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Cell Stem Cell
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Fishing for “complements” with vascular organoid models of microvascular disease
Main text COVID-19, caused by the SARS-CoV-2 virus, has led to an unprecedented global health crisis uniting the medical and scientific communities. Substantial research progress has highlighted the complex pathogenic interplay between viral infections, the immune system, and the vasculature. 1 Gu S.X. Tyagi T. Jain K. Gu V.W. Lee S.H. Hwa J.M. Kwan J.M. Krause D.S. Lee A.I. Halene S. et al. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. , 2 Goshua G.
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
1. Johns Hopkins Coronavirus Resource Center. COVID-19 Dashboard. https://coronavirus.jhu.edu/map.html (2020). 2. Zhu, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727–733 (2020). CAS PubMed PubMed Central Article Google Scholar 3. Wang, C., Horby, P. W., Hayden, F. G. & Gao, G. F. A novel coronavirus outbreak of global health concern. Lancet 395, 470–473 (2020). CAS PubMed PubMed Central Article Google Scholar 4. Wu, Y. et al.
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