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Sebastian Bargfrede on Muck Rack

Sebastian Bargfrede

As seen in: BioRxiv
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Articles

JADE family proteins regulate proteasome abundance and activity

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By Katrin Bohl, Herbert Cohen, Lena Kathrin Ebert, Sebastian Bargfrede
| BioRxiv
Abstract The JADE protein family (JADE1/2/3) has been implicated in a broad range of cellular functions, including WNT signaling, cell cycle control, regulated cell death, and transcriptional regulation through histone acetyltransferase complexes. All three paralogs share high sequence similarity and contain two PHD zinc finger domains. JADE1 has additionally been associated with cilia-related proteins and genetic disorders affecting kidney architecture and function.
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