Sebastian Coleman

Abstract Spontaneous fluctuations in attention can impede adaptation to changing goals and environments. Endogenous control over attentional shifts, referred to as attentional flexibility, is prone to disruption in children with attention deficit disorders. Here we studied in vivo intracranial recordings in children with epilepsy to identify a reproducible neural signature of attentional control that could predict and prevent impending lapses in real time.

Abstract Implantable neurotechnologies are increasingly used to reduce seizure burden in pediatric epilepsy. Vagus nerve stimulation (VNS), the most common option, is effective for only half of patients, with no means to predict outcome prior to surgery. As a result, many children undergo invasive and costly procedures without benefit.

Keywords epilepsy sleep interictal epileptiform discharges closed-loop auditory stimulation phase-locked auditory stimulation response inhibition auditory-evoked response slow oscillations deep sleep real-time detection Introduction Sleep plays a fundamental role in numerous aspects of human health and well-being.