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Sebastiano Bariselli on Muck Rack

Sebastiano Bariselli

As seen in: Nature, Frontiers, Science Magazine, BioRxiv, JNeurosci
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Articles

Motor cortex somatostatin interneurons adaptively shape the structure of action sequences

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By Jeong Oen Lee, Sebastiano Bariselli, Giacomo Sitzia, Abigail Holder, David M. Lovinger
| Nature Verified
Abstract The brain flexibly reorganizes action sequences to optimize behavioral outcomes through reinforcement learning and adaptive motor control. Although the primary motor cortex (M1) is essential for skill learning and dexterous movement, how cortical microcircuits refine the timing and structure of action sequences remains unclear.
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Motor cortex somatostatin interneurons adaptively shape the structure of motor sequences

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By Jeong Oen Lee, Sebastiano Bariselli, Giacomo Sitzia, David M. Lovinger
| BioRxiv
Abstract The brain can flexibly reorganize motor sequence, or program, execution to efficiently reach positive outcomes. These behavioral adaptations are primarily driven by reinforcement learning, leading to structural and kinematic modifications of consolidated motor programs.
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Chronic alcohol induces subcircuit-specific striatonigral plasticity shifting action control to the sensorimotor striatum

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By Giacomo Sitzia, Sebastiano Bariselli, David M. Lovinger, Alexa Gracias
| BioRxiv
Abstract While cortico-striatal circuit deficits contribute to Alcohol Use Disorder, the impact of alcohol on synaptic function in the basal ganglia output, the substantia nigra pars reticulata (SNr), remains unclear. Here, we found that the inputs from the dorsomedial (DMS) and dorsolateral striatum (DLS) differ in their presynaptic properties and target molecularly distinct subpopulations of SNr neurons.
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